Recombinant pig TFPI efficiently regulates human tissue factor pathways
نویسندگان
چکیده
منابع مشابه
Recent Progress on Tissue Factor Pathway Inhibitor (TFPI)
外 因 系凝 固 の 開 始 反 応 で あ る組 織 因子 に よ る VII因 子 お よびX因 子 の 活 性 化 を特 異 的 に 阻 害 す る プ ロ テ ア ー ゼ イ ン ヒ ビタ ー の 存 在 は 古 くか ら指 摘 さ れ て きた が,そ の性 質 は長 い 間 明 らか で は な か っ た.そ の後,Brozeら の研 究 に よ り, そ の イ ン ヒ ビタ ー はXa因 子 依 存 性 にVII因 子 の 活 性 化 を阻 害 す る作 用 を もつ とい う一 見,極 め て 奇 妙 な イ ン ヒ ビタ ー で あ る こ とが 明 らか に な っ て きた.1988年 に彼 らに よ り,そ の ア ミノ 酸 配 列 が 決 定 さ れ,そ れ 以 後,い くつ か の グル ー プ に よ り ,そ の組 換 え体 が 調 製 され た ...
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ژورنال
عنوان ژورنال: Xenotransplantation
سال: 2008
ISSN: 0908-665X,1399-3089
DOI: 10.1111/j.1399-3089.2008.00476.x